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The Spectral Mass Spectrometry Laboratory has developed an innovative ultrasonic atomization device for the fast and efficient extraction of volatile organic compounds (VOCs) from micro-volume urine samples. Combined with their self-developed proton transfer reaction mass spectrometer (PTR-MS), this system enables rapid and highly sensitive analysis of VOCs in urine droplets. This breakthrough allows for real-time monitoring, making it a powerful tool in medical diagnostics.
Recently, the Medical Physics Center within the Spectral Mass Spectrometry Laboratory made significant progress in body fluid analysis by introducing a novel technique called ultrasonic atomization extraction-proton transfer reaction mass spectrometry (UNE-PTR-MS). This method enables the detection of VOCs in just a single drop of urine with high sensitivity and speed. The findings were published in *Analytical Chemistry* (DOI: 10.1021/acs.analchem.7b04563).
Traditional methods for analyzing VOCs in urine often require large sample volumes or are time-consuming. To overcome these limitations, the researchers designed a simple and cost-effective ultrasonic atomization device that works seamlessly with PTR-MS. This approach offers advantages such as a microliter-level injection volume, sub-second response time, and a nanogram-level detection limit. These features make the technology ideal for detecting disease biomarkers in body fluids and can also be applied to environmental monitoring of volatile substances in water.
Supported by grants from the National Natural Science Foundation of China, the developed devices and methodologies have been patented, highlighting their innovation and potential for broader applications in both medical and environmental fields. This research marks a significant step forward in non-invasive and rapid diagnostic technologies.